Can a woman get pregnant by female bone marrow

Monday, 16 April Maggie Fox Reuters. Scientists have created cells that look like immature sperm. But no-one knows if they will be able to mature and go on to fertilised eggs Image: Science. Stem cells taken from men's bone marrow can be coaxed into something that resembles an immature sperm cell, researchers working in Germany say. They hope to use their findings to come up with new and better fertility treatments for men and women.

SEE VIDEO BY TOPIC: Pregnant Carson woman in desperate need of bone marrow transplant

Content:

• Bone Marrow Stem Cells May be Vital for Pregnancy
• Bone marrow may be the missing piece of the fertility puzzle
• How bone marrow boosts chances of a healthy pregnancy
• Bone stem cells turned into primitive sperm cells
• Will science render men unnecessary?
• Stem Cells and Same Sex Reproduction
• Female sperm
• Sperm Cells Created From Human Bone Marrow

SEE VIDEO BY TOPIC: Scientists Make Sperm Out Of Two Women's Skin!

Bone Marrow Stem Cells May be Vital for Pregnancy

Credit: Getty Images. The study shows that when an egg is fertilized, stem cells leave the bone marrow and travel via the bloodstream to the uterus, where they help transform the uterine lining for implantation. If the lining fails to go through this essential transformation, the embryo cannot implant, and the body terminates the pregnancy. But knowing that bone marrow has a significant role is a paradigm shift. In this study, the researchers were able to prove the physiological relevance of stem cells to pregnancy.

In two mouse models with the Hoxa11 gene defect, which presents in mice as a defective endometrium, the researchers found that a bone marrow transplant from a healthy donor could improve fertility by promoting sufficient decidualization of the endometrium. In mice with only one copy of the defective gene, the transplant saved pregnancies that would otherwise have been lost and increased litter sizes, while in the mice with two bad copies of the gene, which were thus entirely infertile, the transplant caused growth and repair of the defective endometria.

This study was possible due to a methods breakthrough that Tal and Taylor made a few years ago. Before a bone marrow transplant , chemotherapy or radiation clears the body of the existing bone marrow, so that the donor bone marrow can take its place. Though more research is needed prior to clinical trials, Tal and Taylor see hope for the patients they treat for infertility on the clinical side of their practice in this latest advance. Bone marrow can be considered another critical reproductive organ.

This finding opens up a new potential avenue for treatment of a condition that has been untreatable in the past. Leet and Clara Guthrie Patterson Fellowship funded the research.

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Bone marrow may be the missing piece of the fertility puzzle

Credit: Getty Images. The study shows that when an egg is fertilized, stem cells leave the bone marrow and travel via the bloodstream to the uterus, where they help transform the uterine lining for implantation. If the lining fails to go through this essential transformation, the embryo cannot implant, and the body terminates the pregnancy. But knowing that bone marrow has a significant role is a paradigm shift.

Since the late s, scientists have explored how to produce sperm where all of the chromosomes come from a female donor. Creating female sperm was first raised as a possibility in a patent filed in [3] by injecting a woman's cells into a man's testicles, though the patent focused mostly on injecting altered male cells into a man's testes to correct genetic diseases. In , Japanese scientists partially confirmed such techniques by creating chicken female sperm in a similar manner. It is therefore concluded that most of the W-bearing PGC could not differentiate into spermatozoa because of restricted spermatogenesis. One potential roadblock to injecting a woman's cells into a man's testicles is that the man's immune system might attack and destroy the woman's cells.

How bone marrow boosts chances of a healthy pregnancy

Human bone marrow has been used to create early-stage sperm cells for the first time, a scientific step forward that will help researchers understand more about how sperm cells are created. For the experiment, Prof Nayernia and his team took bone marrow from male volunteers and isolated the mesenchymal stem cells. These cells have previously been found to grow into other body tissues such as muscle. They cultured these cells in the laboratory and coaxed them into becoming male reproductive cells, which are scientifically known as 'germ cells'. Genetic markers showed the presence of partly-developed sperm cells called spermatagonial stem cells, which are an early phase of the male germ cell development. In most men, spermatagonial cells eventually develop into mature, functional sperm but this progression was not achieved in this experiment. Earlier research led by Prof Nayernia using mice, published in Laboratory Investigations, also created spermatagonial cells from mouse bone marrow. The cells were transplanted into mouse testes and were observed to undergo early meiosis - cell division - the next stage to them becoming mature sperm cells, although they did not develop further. Talking about his newly published research paper, Prof Nayernia, of Newcastle University, said : "We're very excited about this discovery, particularly as our earlier work in mice suggests that we could develop this work even further. Prof Nayernia says a lengthy process of scientific investigation is required within a reasonable ethical and social framework to be able to take this work to its next stage or to say if it has potential applications in terms of fertility treatments in humans.

Bone stem cells turned into primitive sperm cells

I guess after being told to "Go Fuck Yourself" for so many years, these scientists finally found a way to do it. There will be some interesting debates raging about this one for a long time. I'm of the opinion that on the whole, we are better off with the process of gene mixing than practicing self-eugenics. Since when is human reproduction about strengthening the gene pool, and since when are your "gay friends" inherently unable to reproduce naturally?

Bone marrow failure diseases frequently occur in women who are young and of child bearing age. People with these diseases have legitimate concerns about whether a pregnancy will cause their infants to suffer from the disease or its treatment, or whether their own disease will relapse. But the goal of modern therapy and modern obstetrics is to minimize both maternal and fetal complications. Experience from published reports suggests that in the past ten years, both maternal health and fetal outcomes have improved in women with aplastic anemia and PNH.

Will science render men unnecessary?

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The breakthrough paves the way for lesbian couples to have children that are biologically their own. Researchers at Newcastle upon Tyne University say their technique will help lead to new treatments for infertility. But critics warn that it sidelines men and raises the prospect of babies being born through entirely artificial means. The research centres around stem cells - the body's 'mother' cells which can turn into any other type of cell. According to New Scientist magazine, the scientists want to take stem cells from a woman donor's bone marrow and transform them into sperm through the use of special chemicals and vitamins. Newcastle professor Karim Nayernia has applied for permission to carry out the work and is ready to start the experiments within two months.

Stem Cells and Same Sex Reproduction

Bone marrow-derived cells play a role in changes to the mouse uterus before and during pregnancy, enabling implantation of the embryo and reducing pregnancy loss, according to research published September 12 in the open-access journal PLOS Biology. Although the study was done in mice, it raises the possibility that dysfunction of bone marrow-derived progenitor cells may contribute to implantation failure and pregnancy loss in women. Bone marrow progenitors can become either blood or tissue cells. Within the uterus they differentiate into endometrial tissue cells in the lining of the womb, but until now it was not known if they have a function in pregnancy. Reshef Tal and colleagues from Yale School of Medicine developed a bone marrow transplantation protocol that preserved ovary and reproductive function, allowing them for the first time to track these cells in pregnancy, showing that during pregnancy cells from the bone marrow were preferentially recruited to the uterus and were concentrated near the site of implantation, on the maternal side of the placenta.

It may be hard to get and stay pregnant for some would-be mums, but there is hope. Scientists have discovered the vital role bone marrow plays in pregnancy, which can lead to new therapies in the future. In 10 seconds?

Female sperm

The study shows that when an egg is fertilized, stem cells leave the bone marrow and travel via the bloodstream to the uterus, where they help transform the uterine lining for implantation. If the lining fails to go through this essential transformation, the embryo cannot implant, and the body terminates the pregnancy. But knowing that bone marrow has a significant role is a paradigm shift.

Sperm Cells Created From Human Bone Marrow

Log in Advanced Search. A study in mice suggests that bone marrow-derived stem cells may play a role in establishing pregnancy. The research showed that the stem cells can travel through blood circulation to the uterus, making it more receptive for a new embryo.

Stem cells have generated such an enormous amount of interest, in part, because of their applications related to areas such as fertility and genetics. In that same light, their interest for solving reproductive challenges has also generated a great deal of controversy. This is particularly true in the application of stem cells to facilitate reproduction for gay couples. At present, there are a number of research laboratories that are focused on the creation of cells that are genetically male but have been produced from eggs. Alternately, they are also trying to create sperm from female eggs.

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